publication . Article . 2014

Role of efflux pumps: MexAB-OprM and MexXY(-OprA), AmpC cephalosporinase and OprD porin in non-metallo-β-lactamase producing Pseudomonas aeruginosa isolated from cystic fibrosis and burn patients

Mohammad Aghazadeh; Omid Pajand; Mohammad Reza Nahaei; Tina Hojabri; Tahereh Pirzadeh; Reza Mahdian; Zoya Hojabri; Marveh Rahmati;
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  • Published: 30 Mar 2014 Journal: Infection, Genetics and Evolution, volume 24, pages 187-192 (issn: 1567-1348, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Abstract Purpose of the research In order to gain a better understanding of the role of several mechanisms in antibiotic resistance in Pseudomonas aeruginosa clinical isolates obtained from CF and burn patients, we evaluated gene expression of efflux pumps MexAB-OprM and MexXY(-OprA), the natural β-lactamase AmpC and outer membrane porin protein OprD. Also, the presence of genes encoding Ambler classes A, B β-lactamases and aminoglycoside modifying enzymes (AMEs) was examined. Principal results Piperacillin–tazobactam and amikacin retained the highest in vitro activities among 21 CF and 27 burn P. aeruginosa isolates. Based on Enterobacterial Repetitive Intergen...
Subjects
Medical Subject Headings: biochemical phenomena, metabolism, and nutrition
free text keywords: Microbiology (medical), Genetics, Ecology, Evolution, Behavior and Systematics, Molecular Biology, Microbiology, Infectious Diseases, Biology, Efflux, Aminoglycoside, Carbapenem, medicine.drug, medicine, Antibiotic resistance, Meropenem, Pseudomonas aeruginosa, medicine.disease_cause, Amikacin, Gentamicin
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