publication . Article . 2016

The major diversification of Vγ1.1(+) and Vγ2(+) thymocytes in mice occurs after commitment to the γδ T-cell lineage.

Carsten Geisler; Terkild Buus;
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  • Published: 15 Aug 2016 Journal: European Journal of Immunology, volume 46, pages 2,363-2,375 (issn: 0014-2980, Copyright policy)
  • Publisher: Wiley
Abstract
: γδ T cells are a heterogeneous cell population with different subsets playing specialized and often opposing roles during immune responses. A key question is whether γδ thymocytes are determined for their effector function already at an early stage, before their commitment to the γδ T-cell lineage, or are instructed during their later development. Here, we show that the adult Vγ1.1+ and Vγ2+ γδ T-cell subsets both go through a CD73+ CD24+ development stage, and that the gene regulation involved in lineage commitment is shared by both subsets. We demonstrate that the major subset diversification first occurs after the cells have committed to the γδ T-cell linea...
Subjects
free text keywords: Immunology, Immunology and Allergy
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