publication . Article . 2008

Angiotensin-[1-7]

Carlos M. Ferrario; Marc T. Schiavone; Mahesh C. Khosla;
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  • Published: 26 Nov 2008 Journal: Journal of Cardiovascular Pharmacology, volume 16, pages S19-S24 (issn: 0160-2446, Copyright policy)
  • Publisher: Ovid Technologies (Wolters Kluwer Health)
Abstract
Structure-activity studies of angiotensin II (Ang II) have clearly established that the carboxyl-ter-minal phenylalanine is crucial for activation of angiotensin receptors associated with a broad range of effects including vasoconstriction, aldosterone release, and dipsogenesis. Thus, the heptapeptide angiotensin-[1-7] (Ang-[1-7]) has been classified as an inactive metabolite of the hormone Ang II. This assumption was seriously questioned in light of the report from our laboratory that Ang-[1-7] is the major metabolite of dog brainstem homogenates both in the absence and in the presence of angiotensin-converting enzyme inhibitors. These data raised the possibili...
Subjects
Medical Subject Headings: hormones, hormone substitutes, and hormone antagonistscardiovascular system
free text keywords: Pharmacology, Cardiology and Cardiovascular Medicine, Angiotensin II, Renin–angiotensin system, Vasoconstriction, medicine.symptom, medicine, Endocrinology, medicine.medical_specialty, Angiotensin receptor, Brainstem, Chemistry, Hypothalamus, Internal medicine, Medulla oblongata, Aldosterone, chemistry.chemical_compound
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