publication . Article . 2002

Allosteric Cascade of Spliceosome Activation

David A. Brow;
  • Published: 12 Nov 2002 Journal: Annual Review of Genetics, volume 36, pages 333-360 (issn: 0066-4197, eissn: 1545-2948, Copyright policy)
  • Publisher: Annual Reviews
▪ Abstract Introns are removed from precursor messenger RNAs in the cell nucleus by a large ribonucleoprotein complex called the spliceosome. The spliceosome contains five subcomplexes called snRNPs, each with one RNA and several protein components. Interactions of the snRNPs with each other and the intron are highly dynamic, changing in an ordered progression throughout the splicing process. This allosteric cascade of interactions is programmed into the RNA and protein components of the spliceosome, and is driven by a family of DExD/H-box RNA-dependent ATPases. The dependence of cascade progression on multiple intron-recognition events likely serves to enforce ...
free text keywords: Genetics
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