publication . Article . 1996

Diagnosing Creutzfeldt-Jakob disease

R. Will; M. Zeidler;
Open Access
  • Published: 05 Oct 1996 Journal: BMJ, volume 313, pages 833-834 (issn: 0959-8138, eissn: 1468-5833, Copyright policy)
  • Publisher: BMJ
Abstract
Case identification depends on neurological and neuropathological assessment Central to the identification and classification of patients with Creutzfeldt-Jakob disease (CJD) is the application of standardised diagnostic criteria based on accumulated data on the clinical and pathological features of the disease. Typically, patients present clinically with rapidly progressive dementia and myoclonus associated with various focal neurological signs. The diagnosis is confirmed by identifying characteristic neuropathological features, which include spongiform change, astrocytic gliosis, and neuronal loss. Diagnostic criteria originally proposed in 19791 have been val...
Subjects
Medical Subject Headings: mental disordersnervous system diseases
free text keywords: General Medicine, Astrocytic gliosis, Gold standard, Pathological, Clinical diagnosis, Pathology, medicine.medical_specialty, medicine, Disease surveillance, Neurological signs, Myoclonus, medicine.symptom, Disease, business.industry, business
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