publication . Article . 2014

Origins of γδ T Cell Effector Subsets: A Riddle Wrapped in an Enigma

David Wiest; Shawn Fahl;
Open Access
  • Published: 17 Oct 2014 Journal: The Journal of Immunology, volume 193, pages 4,289-4,294 (issn: 0022-1767, eissn: 1550-6606, Copyright policy)
  • Publisher: The American Association of Immunologists
αβ and γδ T cells are thought to arise from a common precursor in the thymus but play distinct roles in pathogen resistance. Although conventional αβ T cells exit the thymus in a naive state and acquire effector function in the periphery, the effector fate of many γδ T cells is specified in the thymus and exhibits limited plasticity thereafter. This review describes the current models that have been proposed to explain the acquisition of effector fate by γδ T cells, as well as the apparent linkage to Vγ gene usage. The two predominant models are the predetermination model, which suggests that effector fate is determined prior to TCR expression, perhaps in associ...
free text keywords: Immunology
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