publication . Article . 2002

Determination of some histamine H1-receptor antagonists in dosage forms.

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  • Published: 07 Oct 2002 Journal: Journal of Pharmaceutical and Biomedical Analysis, volume 30, pages 859-867 (issn: 0731-7085, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Three simple and accurate methods are presented for determination of Cetirizine, Fexofenadine, Loratadine and Acrivastine in pure form and commercial dosage forms. The first method is based on the reaction of the above cited drugs with bromocresol purple dye to form ion-pair complex extractable with chloroform and subsequently measured spectrophotometrically. Secondly, eosin gives with these drugs ion-pair complex, measurable directly without extraction both spectrophotometrically and spectrofluorimetrically. The last method involves the base-catalysed condensation of mixed anhydrides of organic acids (citric acid/acetic anhydride) where as the tertiary amino gr...
Subjects
free text keywords: Analytical Chemistry, Spectroscopy, Clinical Biochemistry, Drug Discovery, Pharmaceutical Science
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