publication . Article . 2016

cognitive and functional changes associated with aβ pathology and the progression to mild cognitive impairment

Philip S. Insel; Michael C. Donohue; R. Scott Mackin; Paul S. Aisen; Oskar Hansson; Michael W. Weiner; Niklas Mattsson;
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  • Published: 31 Aug 2016 Journal: Neurobiology of Aging, volume 48, pages 172-181 (issn: 0197-4580, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Cognitively-normal people with evidence of β-amyloid (Aβ) pathology and subtle cognitive dysfunction are believed to be at high risk for progression to mild cognitive impairment due to Alzheimer's disease (AD). Clinical trials in later stages of AD typically include a coprimary endpoint to demonstrate efficacy on both cognitive and functional assessments. Recent trials focus on cognitively-normal people, but functional decline has not been explored for trial designs in this group. The goal of this study was therefore to characterize cognitive and functional decline in (1) cognitively-normal people converting to mild cognitive impairment (MCI) and (2) cognitively...
Subjects
free text keywords: Cognitive impairment, Psychology, Clinical trial, Disease, Cognition, Statistical power, Pathology, medicine.medical_specialty, medicine, Population, education.field_of_study, education, Sample size determination, Neurology
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