publication . Article . 1994

Extrapyramidal Signs and Psychiatric Symptoms Predict Faster Cognitive Decline in Alzheimer's Disease

Eugene Sobel; Helena Chang Chui; Scott A. Lyness; Lon S. Schneider;
  • Published: 01 Jul 1994 Journal: Archives of Neurology, volume 51, pages 676-681 (issn: 0003-9942, Copyright policy)
  • Publisher: American Medical Association (AMA)
Objective: To identify clinical predictors of cognitive decline in Alzheimer's disease. Design: A cohort of patients was followed up longitudinally and the likelihood of arriving at two cognitive end points was assessed using the Cox proportional hazards model and eight explanatory variables. Setting: Subjects were chosen from patients examined for memory loss at two medical centers affiliated with the University of Southern California, Los Angeles. Patients: The sample included 135 patients who met National Institute for Neurological and Communicative Disorders and Stroke—Alzheimer's Disease and Related Disorders Association criteria for probable or definite Al...
free text keywords: Arts and Humanities (miscellaneous), Clinical Neurology, Psychomotor agitation, medicine.symptom, medicine, Cognitive disorder, medicine.disease, Confidence interval, Cognitive decline, Psychiatry, medicine.medical_specialty, Alzheimer's disease, Proportional hazards model, Cohort, Dementia, Psychology
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