publication . Article . 2002

Estimating a treatment effect in survival studies in which patients switch treatment

Michael Branson; John Whitehead;
  • Published: 27 Aug 2002 Journal: Statistics in Medicine, volume 21, pages 2,449-2,463 (issn: 0277-6715, eissn: 1097-0258, Copyright policy)
  • Publisher: Wiley
: For disease indications such as Acquired Immune Deficiency Syndrome (AIDS) and various cancers, randomization to a pure control treatment may be scientifically desirable but not ethically acceptable. Clinicians may insist that the experimental treatment be made available, at least as a rescue medication, for all patients in the control arm. A method for estimating a treatment effect in survival data from randomized clinical trials of this type is developed under an accelerated failure time model. This approach retains all patients in the groups to which they were randomized and is not based on an ad hoc subgroup analysis. By conditioning on having observed pat...
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