publication . Article . 2008

contact density affects protein evolutionary rate from bacteria to animals

Tong Zhou; D. Allan Drummond; Claus O. Wilke;
  • Published: 31 Mar 2008 Journal: Journal of Molecular Evolution, volume 66, pages 395-404 (issn: 0022-2844, eissn: 1432-1432, Copyright policy)
  • Publisher: Springer Science and Business Media LLC
The density of contacts or the fraction of buried sites in a protein structure is thought to be related to a protein’s designability, and genes encoding more designable proteins should evolve faster than other genes. Several recent studies have tested this hypothesis but have found conflicting results. Here, we investigate how a gene’s evolutionary rate is affected by its protein’s contact density, considering the four species Escherichia coli, Saccharomyces cerevisiae, Drosophila melanogaster, and Homo sapiens. We find for all four species that contact density correlates positively with evolutionary rate, and that these correlations do not seem to be confounded...
free text keywords: Genetics, Ecology, Evolution, Behavior and Systematics, Molecular Biology, Protein structure, Gene, Protein domain, Drosophila Protein, Sequence alignment, Homo sapiens, Saccharomyces cerevisiae, biology.organism_classification, biology, Drosophila melanogaster
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