publication . Article . 2002

The accuracy of ribosomal RNA comparative structure models.

Robin R. Gutell; Jamie J. Cannone; Jung C. Lee;
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  • Published: 11 Oct 2002 Journal: Current Opinion in Structural Biology, volume 12, pages 301-310 (issn: 0959-440X, Copyright policy)
  • Publisher: Elsevier BV
Abstract
The determination of the 16S and 23S rRNA secondary structure models was initiated shortly after the first complete 16S and 23S rRNA sequences were determined in the late 1970s. The structures that are common to all 16S rRNAs and all 23S rRNAs were determined using comparative methods from the analysis of thousands of rRNA sequences. Twenty-plus years later, the 16S and 23S rRNA comparative structure models have been evaluated against the recently determined high-resolution crystal structures of the 30S and 50S ribosomal subunits. Nearly all of the predicted covariation-based base pairs, including the regular base pairs and helices, and the irregular base pairs ...
Subjects
free text keywords: Molecular Biology, Structural Biology, 50S, Base pair, Biology, Computational biology, Protein secondary structure, 30S, Ribosomal RNA, Genetics, 23S ribosomal RNA, Helix
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