publication . Article . 2002

Functional anatomy of limbic epilepsy: a proposal for central synchronization of a diffusely hyperexcitable network

Edward H Bertram; De Xing Zhang; Patrick Mangan; Nathan Fountain; David Rempe;
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  • Published: 25 Jul 2002 Journal: Epilepsy Research, volume 32, pages 194-205 (issn: 0920-1211, Copyright policy)
  • Publisher: Elsevier BV
Abstract
The limbic/mesial temporal lobe epilepsy syndrome has been defined as a focal epilepsy, with the implication that there is a well defined focus of onset, traditionally centered around the hippocampus. The pathology of the hippocampus in this syndrome has been well described and a number of physiological abnormalities have been defined in this structure in animal models and humans with epilepsy. However, anatomical and physiological abnormalities have also been described in other limbic sites in this form of epilepsy. Previous studies have shown broadly synchronized or multifocal seizure onset within the limbic system of the animal models and human patients. We h...
Subjects
Medical Subject Headings: nervous systempsychological phenomena and processes
free text keywords: Neurology, Clinical Neurology
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