publication . Article . 2005

Topographically induced direct cell mechanotransduction.

Matthew J. Dalby;
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  • Published: 27 May 2005 Journal: Medical Engineering & Physics, volume 27, pages 730-742 (issn: 1350-4533, Copyright policy)
  • Publisher: Elsevier BV
Abstract
This review is designed to introduce the cytoskeleton and then discuss how mechanical forces may be transduced to the cell nucleus. In addition to this, it also tries to explain current thinking as to how the nucleus turns these mechanical cues into gene changes and is especially interested in mechanotransduction arising from topographically induced morphological changes, specifically nanotopography. Thus, this review also describes cell responses to topography.
Subjects
Medical Subject Headings: sense organs
free text keywords: Biophysics, Biomedical Engineering, Cytoskeleton, Mechanotransduction, Cell biology, Cell, medicine.anatomical_structure, medicine, Regulation of gene expression, Engineering, business.industry, business, Nucleus, Cell adhesion, Anatomy, Nanotopography
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