publication . Article . 2007

the heterogeneity of amyotrophic lateral sclerosis a possible explanation of treatment failure

Ettore Beghi; Tiziana Mennini; Caterina Bendotti; Paolo Bigini; Giancarlo Logroscino; Adriano Chio; Orla Hardiman; Douglas Mitchell; Robert Swingler; Bryan Traynor; ...
  • Published: 01 Dec 2007 Journal: Current Medicinal Chemistry, volume 14, pages 3,185-3,200 (issn: 0929-8673, Copyright policy)
  • Publisher: Bentham Science Publishers Ltd.
Amyotrophic lateral sclerosis (ALS) is a severe clinical condition characterized by upper and lower motor neuron degeneration for which there is no truly effective treatment. The absence of an effective treatment can be explained in part by the complex and heterogeneous genetic, biochemical, and clinical features of ALS. While ALS accounts for the majority of the motor neuron diseases, the recognition of disease variants and mimic syndromes may lead to further insights into possible causes for the generality of ALS. From a biochemical perspective, the process of motor neuron degeneration is complex and the multifactorial influences and potential biomarkers of AL...
free text keywords: Molecular Medicine, Pharmacology, Amyotrophic lateral sclerosis, medicine.disease, medicine, Risk factor, Disease, Ciliary neurotrophic factor, biology.protein, biology, Endocrinology, medicine.medical_specialty, Biomarker (medicine), Pathological, Degenerative disease, business.industry, business, Neuroscience, Internal medicine, Motor neuron, medicine.anatomical_structure
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