publication . Article . 2005

haematopoietic stem cells and repair of the ischaemic heart

Leora B. Balsam; Robert C. Robbins;
Open Access
  • Published: 23 Nov 2005 Journal: Clinical Science, volume 109, pages 483-492 (issn: 0143-5221, eissn: 1470-8736, Copyright policy)
  • Publisher: Portland Press Ltd.
Abstract
<jats:p>HSCs (haematopoietic stem cells) are multipotent stem cells that give rise to all cells of the blood cell lineage. In recent years, it has been proposed that bone marrow serves as a reservoir for cardiomyogenic precursors and that, following cardiac injury, these stem cells circulate to the site of injury where they contribute to myocardial repair and regeneration. This concept of stem cell plasticity has been controversial and, in fact, several key studies on the cardiomyogenic potential of HSCs have not been reproducible in the hands of independent investigators. Despite this controversy, the clinical community has pushed forward with clinical trials o...
Subjects
free text keywords: General Medicine, Heart failure, medicine.disease, medicine, Blood cell, medicine.anatomical_structure, Heart disease, Multipotent Stem Cell, business.industry, business, Endocrinology, medicine.medical_specialty, Internal medicine, Bone marrow, Regenerative medicine, Pathology, Haematopoiesis, Bioinformatics, Stem cell
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