publication . Article . 2007

Herpesviruses in asymptomatic apical periodontitis lesions: an immunohistochemical approach

C. J. Saboia-Dantas; L. F. Coutrin de Toledo; H. R. Sampaio-Filho; J. F. Siqueira;
  • Published: 03 Sep 2007 Journal: Oral Microbiology and Immunology, volume 22, pages 320-325 (issn: 0902-0055, eissn: 1399-302X, Copyright policy)
  • Publisher: Wiley
Introduction:  Human cytomegalovirus (HCMV) and Epstein–Barr virus (EBV) have been recently detected in samples from apical periodontitis lesions by means of molecular biology techniques and a role in the pathogenesis of this disease has been suggested. The present study was designed to survey asymptomatic primary apical periodontitis lesions for the presence of HCMV- and/or EBV-infected cells by means of immunohistochemistry. Methods:  Apical periodontitis lesions were obtained from 35 patients [26 human immunodeficiency virus (HIV) -seronegative patients and nine HIV-seropositive patients] after tooth extraction and subjected to immunohistochemical analysis us...
Medical Subject Headings: virus diseasesviruses
free text keywords: Epstein–Barr virus, medicine.disease_cause, medicine, Pathology, medicine.medical_specialty, Immunology, Betaherpesvirinae, biology.organism_classification, biology, Human cytomegalovirus, medicine.disease, Gammaherpesvirinae, Lesion, medicine.symptom, Herpesviridae, Asymptomatic, Periodontitis
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