publication . Article . 2007

recent advances in understanding the role of serotonin in gastrointestinal motility in functional bowel disorders alterations in 5 ht signalling and metabolism in human disease

r. spiller;
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  • Published: 07 Jul 2007 Journal: Neurogastroenterology & Motility, volume 19, pages 25-31 (issn: 1350-1925, eissn: 1365-2982, Copyright policy)
  • Publisher: Wiley
Abstract
Abstract  Serotonin (5-hydroxytryptamine, 5-HT) is present in abundance within the gut, most stored in enterochromaffin cell granules. It is released by a range of stimuli, most potently by mucosal stroking. Released 5-HT stimulates local enteric nervous reflexes to initiate secretion and propulsive motility. It also acts on vagal afferents altering motility and in large amounts induces nausea. Rapid reuptake by a specific transporter (serotonin transporter, SERT) limits its diffusion and actions. Abnormally increased 5-HT is found in a range of gastrointestinal disorders including chemotherapy-induced nausea and vomiting, carcinoid syndrome, coeliac disease, in...
Subjects
free text keywords: Prucalopride, medicine.drug, medicine, Enterochromaffin cell, Irritable bowel syndrome, medicine.disease, Serotonin transporter, biology.protein, biology, Serotonin, Carcinoid syndrome, business.industry, business, Reuptake, Endocrinology, medicine.medical_specialty, Internal medicine, Tegaserod
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