publication . Article . Preprint . 2020

Genome-Wide Identification of a Regulatory Mutation in BMP15 Controlling Prolificacy in Sheep

Louise Chantepie; Loys Bodin; Julien Sarry; Florent Woloszyn; Florence Plisson-Petit; Julien Ruesche; Laurence Drouilhet; Stéphane Fabre;
Open Access
  • Published: 19 Jun 2020 Journal: Frontiers in Genetics, volume 11 (eissn: 1664-8021, Copyright policy)
  • Publisher: Frontiers Media SA
  • Country: France
Abstract
AbstractThe search for the genetic determinism of prolificacy variability in sheep has evidenced several major mutations in genes playing a crucial role in the control of ovulation rate. In the Noire du Velay (NV) sheep population, a recent genetic study has evidenced the segregation of such a mutation named FecLL. However, based on litter size (LS) records of FecLL non-carrier ewes, the segregation of a second prolificacy major mutation was suspected in this population. In order to identify this mutation, we have combined case/control genome-wide association study with ovine 50k SNP chip genotyping, whole genome sequencing and functional analyses. A new single ...
Subjects
free text keywords: Genetics(clinical), Genetics, Molecular Medicine, génome, sheep, mouton, [SDV.BDLR.RS]Life Sciences [q-bio]/Reproductive Biology/Sexual reproduction, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics, GWAS, major gene, prolificacy, BMP15, [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT], Original Research, Biology, SNP genotyping, Single-nucleotide polymorphism, Genetics, Genome-wide association study, X chromosome, Population, education.field_of_study, education, Mutation, medicine.disease_cause, medicine, Allele frequency, Major gene, Gene, Genetic determinism, lcsh:Genetics, lcsh:QH426-470
38 references, page 1 of 3

10. Abdoli R, Zamani P, Mirhoseini SZ, Ghavi Hossein-Zadeh N, Nadri S. A review on prolificacy genes in sheep. Reprod Domest Anim Zuchthyg. 2016;51: 631-637. doi:10.1111/rda.12733

11. Galloway SM, McNatty KP, Cambridge LM, Laitinen MPE, Juengel JL, Jokiranta TS, et al. Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner. Nat Genet. 2000;25: 279-283. doi:10.1038/77033

12. Hanrahan JP, Gregan SM, Mulsant P, Mullen M, Davis GH, Powell R, et al. Mutations in the Genes for Oocyte-Derived Growth Factors GDF9 and BMP15 Are Associated with Both Increased Ovulation Rate and Sterility in Cambridge and Belclare Sheep (Ovis aries)1. Biol Reprod. 2004;70: 900-909. doi:10.1095/biolreprod.103.023093

13. Silva BDM, Castro EA, Souza CJH, Paiva SR, Sartori R, Franco MM, et al. A new polymorphism in the Growth and Differentiation Factor 9 (GDF9) gene is associated with increased ovulation rate and prolificacy in homozygous sheep. Anim Genet. 42: 89-92. doi:10.1111/j.1365- 2052.2010.02078.x

14. Demars J, Fabre S, Sarry J, Rossetti R, Gilbert H, Persani L, et al. Genome-wide association studies identify two novel BMP15 mutations responsible for an atypical hyperprolificacy phenotype in sheep. PLoS Genet. 2013;9: e1003482. doi:10.1371/journal.pgen.1003482 7.

15. Chantepie L, Bodin L, Sarry J, Woloszyn F, Ruesche J, Drouilhet L, et al. Presence of causative mutations affecting prolificacy in the Noire du Velay and Mouton Vendéen sheep breeds. Livest Sci. 2018;216: 44-50. doi:10.1016/j.livsci.2018.07.007 [OpenAIRE]

16. Drouilhet L, Mansanet C, Sarry J, Tabet K, Bardou P, Woloszyn F, et al. The Highly Prolific Phenotype of Lacaune Sheep Is Associated with an Ectopic Expression of the B4GALNT2 Gene within the Ovary. PLOS Genet. 2013;9: e1003809. doi:10.1371/journal.pgen.1003809

17. Bodin L, Di Pasquale E, Fabre S, Bontoux M, Monget P, Persani L, et al. A novel mutation in the bone morphogenetic protein 15 gene causing defective protein secretion is associated with both increased ovulation rate and sterility in Lacaune sheep. Endocrinology. 2007;148: 393- 400. doi:10.1210/en.2006-0764

18. Wilson T, Wu XY, Juengel JL, Ross IK, Lumsden JM, Lord EA, et al. Highly prolific Booroola sheep have a mutation in the intracellular kinase domain of bone morphogenetic protein IB receptor (ALK-6) that is expressed in both oocytes and granulosa cells. Biol Reprod. 2001;64: 1225-1235.

19. Talebi R, Ahmadi A, Afraz F, Sarry J, Plisson-Petit F, Genêt C, et al. Transcriptome analysis of ovine granulosa cells reveals differences between small antral follicles collected during the

20. Davis GH, Galloway SM, Ross IK, Gregan SM, Ward J, Nimbkar BV, et al. DNA tests in prolific sheep from eight countries provide new evidence on origin of the Booroola (FecB) mutation. Biol Reprod. 2002;66: 1869-1874. doi:10.1095/biolreprod66.6.1869

21. Mullen MP, Hanrahan JP, Howard DJ, Powell R. Investigation of prolific sheep from UK and Ireland for evidence on origin of the mutations in BMP15 (FecX(G), FecX(B)) and GDF9 (FecG(H)) in Belclare and Cambridge sheep. PloS One. 2013;8: e53172. doi:10.1371/journal.pone.0053172

22. Jemaa SB, Ruesche J, Sarry J, Woloszyn F, Lassoued N, Fabre S. The high prolificacy of D'man sheep is associated with the segregation of the FecLL mutation in the B4GALNT2 gene. Reprod Domest Anim. 2018;0. doi:10.1111/rda.13391

23. Rochus CM, Tortereau F, Plisson-Petit F, Restoux G, Moreno-Romieux C, Tosser-Klopp G, et al. Revealing the selection history of adaptive loci using genome-wide scans for selection: an example from domestic sheep. BMC Genomics. 2018;19. doi:10.1186/s12864-018-4447-x

24. Bonnet A, Cabau C, Bouchez O, Sarry J, Marsaud N, Foissac S, et al. An overview of gene expression dynamics during early ovarian folliculogenesis: specificity of follicular compartments and bi-directional dialog. BMC Genomics. 2013;14: 904. doi:10.1186/1471-2164-14-904

38 references, page 1 of 3
Any information missing or wrong?Report an Issue