publication . Article . Preprint . 2020

Genome-Wide Identification of a Regulatory Mutation in BMP15 Controlling Prolificacy in Sheep

Louise Chantepie; Loys Bodin; Julien Sarry; Florent Woloszyn; Florence Plisson-Petit; Julien Ruesche; Laurence Drouilhet; Stéphane Fabre;
Open Access
  • Published: 19 Jun 2020 Journal: Frontiers in Genetics, volume 11 (eissn: 1664-8021, Copyright policy)
  • Publisher: Frontiers Media SA
  • Country: France
AbstractThe search for the genetic determinism of prolificacy variability in sheep has evidenced several major mutations in genes playing a crucial role in the control of ovulation rate. In the Noire du Velay (NV) sheep population, a recent genetic study has evidenced the segregation of such a mutation named FecLL. However, based on litter size (LS) records of FecLL non-carrier ewes, the segregation of a second prolificacy major mutation was suspected in this population. In order to identify this mutation, we have combined case/control genome-wide association study with ovine 50k SNP chip genotyping, whole genome sequencing and functional analyses. A new single ...
free text keywords: Genetics(clinical), Genetics, Molecular Medicine, génome, sheep, mouton, [SDV.BDLR.RS]Life Sciences [q-bio]/Reproductive Biology/Sexual reproduction, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics, GWAS, major gene, prolificacy, BMP15, [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT], Original Research, Biology, SNP genotyping, Single-nucleotide polymorphism, Genetics, Genome-wide association study, X chromosome, Population, education.field_of_study, education, Mutation, medicine.disease_cause, medicine, Allele frequency, Major gene, Gene, Genetic determinism, lcsh:Genetics, lcsh:QH426-470
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