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BMC Medical Genetics
Article
License: CC BY
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BMC Medical Genetics
Other literature type . 2014
Data sources: NARCIS
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BMC Medical Genetics
Article . 2014 . Peer-reviewed
License: CC BY
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The impact of coronary artery disease risk loci on ischemic heart failure severity and prognosis: association analysis in the COntrolled ROsuvastatin multiNAtional trial in heart failure (CORONA)

association analysis in the COntrolled ROsuvastatin multiNAtional trial in heart failure (CORONA)
Authors: Haver, Vincent G; Verweij, Niek; Kjekshus, John; Fox, Jayne C; Wedel, Hans; Wikstrand, John; van Gilst, Wiek H; +3 Authors

The impact of coronary artery disease risk loci on ischemic heart failure severity and prognosis: association analysis in the COntrolled ROsuvastatin multiNAtional trial in heart failure (CORONA)

Abstract

Background Recent genome-wide association studies have identified multiple loci that are associated with an increased risk of developing coronary artery disease (CAD). The impact of these loci on the disease severity and prognosis of ischemic heart failure due to CAD is currently unknown. Methods We undertook association analysis of 7 single nucleotide polymorphism (rs599839, rs17465637, rs2972147, rs6922269, rs1333049, rs501120, and rs17228212) at 7 well established CAD risk loci (1p13.3, 1q41, 2q36.3, 6q25.1, 9p21.3, 10q11.21, and 15q22.33, respectively) in 3,320 subjects diagnosed with systolic heart failure of ischemic aetiology and participating in the COntrolled ROsuvastatin multiNAtional Trial in Heart Failure (CORONA) trial. The primary outcome was the composite of time to first event of cardiovascular death, non-fatal myocardial infarction and non-fatal stroke, secondary outcomes included mortality and hospitalization due to worsening heart failure. Results None of the 7 loci were significantly associated with the primary composite endpoint of the CORONA trial (death from cardiovascular cases, nonfatal myocardial infarction, and nonfatal stroke). However, the 1p13.3 locus (rs599839) showed evidence for association with all-cause mortality (after adjustment for covariates; HR 0.74, 95%CI [0.61 to 0.90]; P = 0.0025) and we confirmed the 1p13.3 locus (rs599839) to be associated with lipid parameters (total cholesterol (P = 1.1x10−4), low-density lipoprotein levels (P = 3.5 × 10−7) and apolipoprotein B (P = 2.2 × 10−10)). Conclusion Genetic variants strongly associated with CAD risk are not associated with the severity and outcome of ischemic heart failure. The observed association of the 1p13.3 locus with all-cause mortality requires confirmation in further studies.

Country
Netherlands
Subjects by Vocabulary

Microsoft Academic Graph classification: medicine.medical_specialty Cardiomyopathy Coronary artery disease chemistry.chemical_compound Internal medicine medicine Rosuvastatin Myocardial infarction Framingham Risk Score business.industry Cholesterol medicine.disease chemistry Heart failure Cardiology Etiology business medicine.drug

Keywords

Male, SUSCEPTIBILITY LOCI, SNP, Heart failure, Coronary Artery Disease, Polymorphism, Single Nucleotide, 9P21, DESIGN, Healthy ageing, Genetics, Humans, Genetics(clinical), Genetic Predisposition to Disease, Genetics (clinical), Aged, Aged, 80 and over, Clinical Trials as Topic, CARDIOMYOPATHY, CHOLESTEROL, Middle Aged, Prognosis, Research Article, Heart Failure, Systolic

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  • citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    10
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
10
Top 10%
Average
Average
Green
gold