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Pregnancy in Charcot-Marie-Tooth disease: Data from the Italian CMT national registry
Pregnancy in Charcot-Marie-Tooth disease: Data from the Italian CMT national registry
ObjectiveTo collect information on frequency of pregnancy and delivery complications in Charcot-Marie-Tooth (CMT) disease and on CMT course during pregnancy.MethodsThrough an ad hoc online questionnaire, we investigated pregnancy and neuropathy course in women with CMT adhering to the Italian CMT Registry. Data were compared to those of controls (recruited among friends and unaffected relatives) and the Italian (or other reference) population.ResultsWe collected data on 193 pregnancies from 86 women with CMT (age 20–73 years) with 157 deliveries (81.4%) after a mean of 38.6 gestational weeks. In women with CMT, there were no differences compared to controls (59 pregnancies and 46 deliveries from 24 controls) and the reference population for miscarriages (11.4%) and planned (21.0%) and emergency (14.0%) cesarean sections. We found a significantly higher frequency of placenta previa (1.6% vs 0.4%), abnormal fetal presentations (8.4% vs 4.5%), and preterm deliveries (20.3% vs 6.9%; most in week 34–36 of gestation) compared to reference populations. Excluding twins, newborn weight did not differ from the reference population. Postpartum bleeding rate in patients with CMT (2.1%) was similar to that of the general population (2.4%). CMT status worsened during 18 of 193 pregnancies (9.3%) with no recovery in 16 of them and with similar figures in the CMT1A and non-CMT1A subtypes.ConclusionsWe observed higher rates of placenta previa, abnormal presentations, and preterm deliveries in CMT, but pregnancy outcome and newborn weight and health were similar to those of the reference populations. Worsening of CMT is not infrequent and occurs not only in CMT1A. Pregnant women with CMT should be monitored with particular care.
Microsoft Academic Graph classification: education.field_of_study postpartum bleeding Obstetrics Gestational age Premature birth Gestation medicine.medical_specialty Birth weight Population medicine education Pregnancy business.industry medicine.disease Placenta previa business
Medical Subject Headings: congenital, hereditary, and neonatal diseases and abnormalities nervous system diseases
Registrie, Placenta Previa, Retrospective Studie, Charcot-Marie-Tooth Disease, Pregnancy, Abortion, Spontaneou, Birth Weight, Registries, Obstetric Labor Complication, disease course, Pregnancy Outcome, Middle Aged, Symptom Flare Up, Italy, Pregnancy; Charcot-Marie-Tooth disease, Premature Birth, Female, Human, Adult, Gestational Age, -, Article, Young Adult, Humans, delivery complications, Breech Presentation, Aged, Retrospective Studies, Cesarean Section, Postpartum Hemorrhage, Infant, Newborn, Obstetric Labor Complications, Abortion, Spontaneous, Neurology (clinical)
Registrie, Placenta Previa, Retrospective Studie, Charcot-Marie-Tooth Disease, Pregnancy, Abortion, Spontaneou, Birth Weight, Registries, Obstetric Labor Complication, disease course, Pregnancy Outcome, Middle Aged, Symptom Flare Up, Italy, Pregnancy; Charcot-Marie-Tooth disease, Premature Birth, Female, Human, Adult, Gestational Age, -, Article, Young Adult, Humans, delivery complications, Breech Presentation, Aged, Retrospective Studies, Cesarean Section, Postpartum Hemorrhage, Infant, Newborn, Obstetric Labor Complications, Abortion, Spontaneous, Neurology (clinical)
Microsoft Academic Graph classification: education.field_of_study postpartum bleeding Obstetrics Gestational age Premature birth Gestation medicine.medical_specialty Birth weight Population medicine education Pregnancy business.industry medicine.disease Placenta previa business
Medical Subject Headings: congenital, hereditary, and neonatal diseases and abnormalities nervous system diseases
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).7 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10% citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).7 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!- National Research Council Italy
- University of Messina Italy
- University of Genoa Italy
- University Federico II of Naples Italy
- Catholic University of the Sacred Heart Italy
- University of Verona Italy
- Magna Graecia University Italy
- Institute of Molecular Bioimaging and Physiology Italy
- Vita-Salute San Raffaele University Italy
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Italy
ObjectiveTo collect information on frequency of pregnancy and delivery complications in Charcot-Marie-Tooth (CMT) disease and on CMT course during pregnancy.MethodsThrough an ad hoc online questionnaire, we investigated pregnancy and neuropathy course in women with CMT adhering to the Italian CMT Registry. Data were compared to those of controls (recruited among friends and unaffected relatives) and the Italian (or other reference) population.ResultsWe collected data on 193 pregnancies from 86 women with CMT (age 20–73 years) with 157 deliveries (81.4%) after a mean of 38.6 gestational weeks. In women with CMT, there were no differences compared to controls (59 pregnancies and 46 deliveries from 24 controls) and the reference population for miscarriages (11.4%) and planned (21.0%) and emergency (14.0%) cesarean sections. We found a significantly higher frequency of placenta previa (1.6% vs 0.4%), abnormal fetal presentations (8.4% vs 4.5%), and preterm deliveries (20.3% vs 6.9%; most in week 34–36 of gestation) compared to reference populations. Excluding twins, newborn weight did not differ from the reference population. Postpartum bleeding rate in patients with CMT (2.1%) was similar to that of the general population (2.4%). CMT status worsened during 18 of 193 pregnancies (9.3%) with no recovery in 16 of them and with similar figures in the CMT1A and non-CMT1A subtypes.ConclusionsWe observed higher rates of placenta previa, abnormal presentations, and preterm deliveries in CMT, but pregnancy outcome and newborn weight and health were similar to those of the reference populations. Worsening of CMT is not infrequent and occurs not only in CMT1A. Pregnant women with CMT should be monitored with particular care.