publication . Article . 2002

Surface proteins and the pathogenic potential of Listeria monocytogenes

Didier Cabanes; Pierre Dehoux; Olivier Dussurget; Lionel Frangeul; Pascale Cossart;
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  • Published: 17 Apr 2002
  • Publisher: HAL CCSD
  • Country: France
Abstract
International audience; On the basis of the recently determined genome sequence of Listeria monocytogenes, we performed a global analysis of the surface-protein-encoding genes. Only proteins displaying a signal peptide were taken into account. Forty-one genes encoding LPXTG proteins, including the previously known internalin gene family, were detected. Several genes encoding proteins that, like InlB and Ami, possess GW modules that attach them to lipoteichoic acids were also identified. Additionally, the completed genome sequence revealed genes encoding proteins potentially anchored in the cell membrane by a hydrophobic tail as well as genes encoding P60-like pr...
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free text keywords: LPXTG proteins, Internalin, PKD repeats, RGD motifs, GW modules, Sortases, P60-like proteins, Bioinformatics, Microbiology, MESH: Amino Acid Motifs, MESH: Amino Acid Sequence, MESH: Bacterial Proteins, MESH: Humans, MESH: Lipoproteins, MESH: Listeria monocytogenes, MESH: Membrane Proteins, MESH: Molecular Sequence Data, MESH: Peptidoglycan, MESH: Sequence Alignment, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Microbiology (medical), Virology, Infectious Diseases, Genetics, Listeria monocytogenes, medicine.disease_cause, medicine, Whole genome sequencing, Internalin, Gene, Gene family, Cell membrane, medicine.anatomical_structure, Signal peptide, Biology
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