publication . Article . Other literature type . 2008

Amorphous calcium phosphate is a major component of the forming fin bones of zebrafish: Indications for an amorphous precursor phase

Julia Mahamid; Amnon Sharir; Lia Addadi; Steve Weiner;
Open Access
  • Published: 27 Aug 2008
  • Publisher: Proceedings of the National Academy of Sciences
Abstract
A fundamental question in biomineralization is the nature of the first-formed mineral phase. In vertebrate bone formation, this issue has been the subject of a long-standing controversy. We address this key issue using the continuously growing fin bony rays of the Tuebingen long-fin zebrafish as a model for bone mineralization. Employing high-resolution scanning and transmission electron microscopy imaging, electron diffraction, and elemental analysis, we demonstrate the presence of an abundant amorphous calcium phosphate phase in the newly formed fin bones. The extracted amorphous mineral particles crystallize with time, and mineral crystallinity increases duri...
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Subjects
free text keywords: Multidisciplinary, Physical Sciences, Biomineralization, Chemistry, Electron diffraction, Mineralogy, Transmission electron microscopy, Amorphous solid, Bone maturation, Crystallinity, Amorphous calcium phosphate, Mineralization (biology), Chemical engineering
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