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Publication . Article . 2007

NCI Thesaurus: A semantic model integrating cancer-related clinical and molecular information

Sioutos, Nicholas; Coronado, Sherri de; Haber, Margaret W.; Hartel, Frank W.; Shaiu, Wen-Ling; Wright, Lawrence W.;
Open Access  
Published: 01 Feb 2007 Journal: Journal of Biomedical Informatics, volume 40, issue 1, pages 30-43 (issn: 1532-0464, Copyright policy )
Publisher: Elsevier BV
Abstract
Over the last 8 years, the National Cancer Institute (NCI) has launched a major effort to integrate molecular and clinical cancer-related information within a unified biomedical informatics framework, with controlled terminology as its foundational layer. The NCI Thesaurus is the reference terminology underpinning these efforts. It is designed to meet the growing need for accurate, comprehensive, and shared terminology, covering topics including: cancers, findings, drugs, therapies, anatomy, genes, pathways, cellular and subcellular processes, proteins, and experimental organisms. The NCI Thesaurus provides a partial model of how these things relate to each other, responding to actual user needs and implemented in a deductive logic framework that can help maintain the integrity and extend the informational power of what is provided. This paper presents the semantic model for cancer diseases and its uses in integrating clinical and molecular knowledge, more briefly examines the models and uses for drug, biochemical pathway, and mouse terminology, and discusses limits of the current approach and directions for future work.
Subjects by Vocabulary

ACM Computing Classification System: ComputingMethodologies_PATTERNRECOGNITION

Microsoft Academic Graph classification: Data science Computer science System integration business.industry business Deductive reasoning Semantics Semantic data model Terminology Vocabulary media_common.quotation_subject media_common MEDLINE Health informatics

Subjects

Health Informatics, Computer Science Applications

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