publication . Preprint . Article . 2020

Genomic measures of inbreeding coefficients and genome-wide scan for runs of homozygosity islands in Iranian river buffalo, Bubalus bubalis

Seyed Mohammad Ghoreishifar; Hossein Moradi-Shahrbabak; Mohammad Hossein Fallahi; Ali Jalil Sarghale; Mohammad Moradi-Shahrbabak; Rostam Abdollahi-Arpanahi; Majid Khansefid;
Open Access
  • Published: 10 Feb 2020
  • Publisher: Research Square Platform LLC
Abstract
Abstract Background Consecutive homozygous fragments of a genome inherited by offspring from a common ancestor are known as runs of homozygosity (ROH). ROH can be used to calculate genomic inbreeding and to identify genomic regions that are potentially under historical selection pressure. The dataset of our study consisted of 254 Azeri (AZ) and 115 Khuzestani (KHZ) river buffalo genotyped for ~ 65,000 SNPs for the following two purposes: 1) to estimate and compare inbreeding calculated using ROH (FROH), excess of homozygosity (FHOM), correlation between uniting gametes (FUNI), and diagonal elements of the genomic relationship matrix (FGRM); 2) to identify freque...
Subjects
free text keywords: Genetics(clinical), Genetics, Research Article, Water buffalo, River buffalo, Genetic diversity, Inbreeding, Gene enrichment, Runs of homozygosity, Selection signatures, lcsh:Genetics, lcsh:QH426-470
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