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Publication . Article . 2018

Safety of cilostazol in peripheral artery disease: a cohort from a primary healthcare electronic database

Jordi Real; M. Catalina Serna; Maria Giner-Soriano; Rosa Forés; Guillem Pera; Esther Ribes; Maite Alzamora; +3 Authors
Open Access
Published: 08 May 2018
Publisher: BioMed Central
Country: Spain

Cilostazol; Peripheral artery disease; Primary healthcare Cilostazol ; Enfermedades Arteriales Periféricas; Atención primaria Cilostazol; Malalties arterials perifèriques; Atenció primària Background: Cilostazol has been associated with spontaneous reports of cardiovascular adverse events and serious bleeding. The objective of this study is to determine the relative risk of cardiovascular adverse events or haemorrhages in patients with peripheral artery disease treated with cilostazol in comparison to pentoxifylline users. Methods: Population-based cohort study including all individuals older than 40 who initiated cilostazol or pentoxifylline during 2009–2011 in SIDIAP database. The two treatment groups were matched through propensity score (PS). Results: Nine thousand one hundred twenty-nine patients met inclusion criteria and after PS matching, there were 2905 patients in each group. 76% of patients were men, with similar mean ages in both groups (68.8 for cilostazol and 69.4 for pentoxifylline). There were no differences in bleeding, cerebrovascular and cardiovascular events between both groups. Conclusions: Patients treated with cilostazol were different from those treated with pentoxifylline at baseline, so they were matched through PS. We did not find differences between treatment groups in the incidence of bleeding or cardiovascular and cerebrovascular events. Cilostazol should be used with precaution in elderly polymedicated patients.

Subjects by Vocabulary

Microsoft Academic Graph classification: Adverse effect Coronary artery disease medicine.disease medicine Internal medicine medicine.medical_specialty Cohort study Pentoxifylline medicine.drug Cilostazol Cohort business.industry business Population education.field_of_study education Relative risk

Library of Congress Subject Headings: lcsh:Diseases of the circulatory (Cardiovascular) system lcsh:RC666-701


Cilostazol, Pentoxifylline, Peripheral artery disease, Primary healthcare, Malalties coronàries - Tractament, Artèries - Malalties - Tractament, Raonament basat en casos, :Cardiovascular Diseases::Vascular Diseases::Peripheral Vascular Diseases [DISEASES], :Heterocyclic Compounds::Heterocyclic Compounds, Fused-Ring::Heterocyclic Compounds, 2-Ring::Purines::Purinones::Xanthines::Theobromine::Pentoxifylline [CHEMICALS AND DRUGS], :Investigative Techniques::Epidemiologic Methods::Data Collection::Records as Topic::Medical Records::Medical Records Systems, Computerized::Electronic Health Records [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT], :enfermedades cardiovasculares::enfermedades vasculares::enfermedades vasculares periféricas [ENFERMEDADES], :Compuestos Heterocíclicos::Compuestos Heterocíclicos de Anillos Fusionados::Compuestos Heterocíclicos con 2 Anillos::Purinas::Purinonas::Xantinas::Teobromina::Pentoxifilina [COMPUESTOS QUÍMICOS Y DROGAS], :Técnicas de Investigación::Métodos Epidemiológicos::Recolección de Datos::Registros como Asunto::Registros Médicos::Sistemas de Registros Médicos Computarizados::Registros Electrónicos de Salud [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Cardiology and Cardiovascular Medicine, :compuestos heterocíclicos::compuestos heterocíclicos con anillos de fusión::compuestos heterocíclicos de 2 anillos::purinas::purinonas::xantinas::teobromina::pentoxifilina [COMPUESTOS QUÍMICOS Y DROGAS], :técnicas de investigación::métodos epidemiológicos::recopilación de datos::registros::registros médicos::sistemas informatizados de historias clínicas::historias clínicas electrónicas [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Cilostazol, Pentoxifylline, Peripheral artery disease, Primary healthcare, Electronic health records, Haemorrhage, Electronic health records, Haemorrhage, Arrhythmia, Cardiovascular events, Coronary artery disease, Research Article, Arrhythmia, Cardiovascular events, Coronary artery disease