Molecular basis of the little mouse phenotype and Implications for cell type-specific growth
Copyright policy )Molecular basis of the little mouse phenotype and Implications for cell type-specific growth
The molecular basis for the little (lit) mouse phenotype, characterized by a hypoplastic anterior pituitary gland, is the mutation of a single nucleotide that alters Asp 60 to Gly in the growth hormone releasing factor receptor. Detailed analysis of the lit mouse anterior pituitary reveals spatially distinct proliferative zones of growth hormone-producing stem cells and mature somatotrophs, each regulated by a different trophic factor. This sequential growth factor requirement for a specific cell type may exemplify a common strategy for regulating cellular proliferation in other mammalian organs.
- University of California, San Diego United States
- University of California, Los Angeles United States
- University of California, San Diego United States
- Howard Hughes Medical Institute United States
- Xiamen University China (People's Republic of)
PANCREATIC-ISLET TUMOR, Male, DNA Mutational Analysis, Molecular Sequence Data, CYCLIC-AMP, PROTEIN, Growth Hormone-Releasing Hormone, HORMONE-RELEASING-FACTOR, Mice, Animals, Amino Acid Sequence, Dwarfism, Pituitary, TRANSGENIC MICE, DWARF MICE, Binding Sites, Base Sequence, Chromosome Mapping, Cell Differentiation, THYROID-CELLS, GENE, Mice, Mutant Strains, DNA-Binding Proteins, Mice, Inbred C57BL, Phenotype, Oligodeoxyribonucleotides, Mutation, ANTERIOR-PITUITARY CELLS, Female, MESSENGER-RNA, Cell Division
PANCREATIC-ISLET TUMOR, Male, DNA Mutational Analysis, Molecular Sequence Data, CYCLIC-AMP, PROTEIN, Growth Hormone-Releasing Hormone, HORMONE-RELEASING-FACTOR, Mice, Animals, Amino Acid Sequence, Dwarfism, Pituitary, TRANSGENIC MICE, DWARF MICE, Binding Sites, Base Sequence, Chromosome Mapping, Cell Differentiation, THYROID-CELLS, GENE, Mice, Mutant Strains, DNA-Binding Proteins, Mice, Inbred C57BL, Phenotype, Oligodeoxyribonucleotides, Mutation, ANTERIOR-PITUITARY CELLS, Female, MESSENGER-RNA, Cell Division
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