Alternative translation initiation site usage results in two functionally distinct forms of the GATA-1 transcription factor.
Copyright policy )Alternative translation initiation site usage results in two functionally distinct forms of the GATA-1 transcription factor.
GATA-1 is a zinc-finger transcription factor that plays a critical role in the normal development of hematopoietic cell lineages. In human and murine erythroid cells a previously undescribed 40-kDa protein is detected with GATA-1-specific antibodies. We show that the 40-kDa GATA-1 (GATA-1s) is produced by the use of an internal AUG initiation codon in the GATA-1 transcript. The GATA-1 proteins share identical binding activity and form heterodimers in erythroleukemic cells but differ in their transactivation potential and in their expression in developing mouse embryos.
Transcriptional Activation, Protein Conformation, Molecular Sequence Data, genomic, Mice, Animals, Humans, genomics; gene expression; transcription factors; translational regulation, GATA1 Transcription Factor, Tissue Distribution, Peptide Chain Initiation, Translational, transcription factor, Cells, Cultured, Base Sequence, Genetic Variation, Embryo, Mammalian, 400, translational regulation, DNA-Binding Proteins, Molecular Weight, gene expression, Erythroid-Specific DNA-Binding Factors, Protein Binding, Transcription Factors
Transcriptional Activation, Protein Conformation, Molecular Sequence Data, genomic, Mice, Animals, Humans, genomics; gene expression; transcription factors; translational regulation, GATA1 Transcription Factor, Tissue Distribution, Peptide Chain Initiation, Translational, transcription factor, Cells, Cultured, Base Sequence, Genetic Variation, Embryo, Mammalian, 400, translational regulation, DNA-Binding Proteins, Molecular Weight, gene expression, Erythroid-Specific DNA-Binding Factors, Protein Binding, Transcription Factors
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