Cheminformatics-based selection and synergism of herbal extracts with anticancer agents on drug resistance tumor cells—ACHN and A2780/CP cell lines
Copyright policy )Cheminformatics-based selection and synergism of herbal extracts with anticancer agents on drug resistance tumor cells—ACHN and A2780/CP cell lines
The treatment of cancer usually involves lethal effect on normal body cells as side effects. Cheminformatics methodology can play a significant role in biomed/clinical scientific research. Similarity searching is a standard cheminformatics tool in drug discovery area and database design. In this study, five novel herbal extracts in combination with doxorubicin and cisplatin have been used to sensitize ACHN and A2780/cp cells. These herbal extracts have been selected on the basis of novel cheminformatics methodology and assayed for the first time. The findings confirmed predicted outcomes from the in silico research and the results introduced may bring to use the effects of these herbs in reversing of multidrug resistance (MDR) phenomenon.
- Biotechnology Research Center Iran (Islamic Republic of)
- Pasteur Institute of Iran Iran (Islamic Republic of)
- Tabriz University of Medical Sciences Iran (Islamic Republic of)
Erythrocytes, Informatics, Computational Biology, Antineoplastic Agents, Drug Synergism, Musa, Adenocarcinoma, Boraginaceae, Hemolysis, Drug Resistance, Multiple, Kidney Neoplasms, Inhibitory Concentration 50, Doxorubicin, Drug Resistance, Neoplasm, Cell Line, Tumor, Animals, Humans, Female, Morus, Cisplatin
Erythrocytes, Informatics, Computational Biology, Antineoplastic Agents, Drug Synergism, Musa, Adenocarcinoma, Boraginaceae, Hemolysis, Drug Resistance, Multiple, Kidney Neoplasms, Inhibitory Concentration 50, Doxorubicin, Drug Resistance, Neoplasm, Cell Line, Tumor, Animals, Humans, Female, Morus, Cisplatin
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