Reply to Lyon et al.: Self-regulation and the foraging gene: From flies to humans
Copyright policy )Reply to Lyon et al.: Self-regulation and the foraging gene: From flies to humans
Below we directly address Lyon et al.’s (1) critique of Struk et al. (2). We do not debate the utility of genome-wide vs. candidate gene studies of complex behavioral phenotypes (3). The Struk et al. (2) paper uses a hypothesis-driven approach to test the association of the rs13499 single-nucleotide polymorphism (SNP) in the PRKG1 gene with the locomotor/assessor self-regulation trait. The test is a straightforward single hypothesis-driven test of one SNP in one gene. Our hypothesis is derived from mechanistic studies of PRKG1 ’s ortholog ( foraging ) in Drosophila and other species (4). From Struk et al.’s (2) analysis of CommonMind data: +SVA (synapse data) a P value of P = … [↵][1]1To whom correspondence may be addressed. Email: jdancker{at}uwaterloo.ca. [1]: #xref-corresp-1-1
- University of Toronto Canada
- University of Waterloo Canada
Humans, Feeding Behavior, Cyclic GMP-Dependent Protein Kinase Type I
Humans, Feeding Behavior, Cyclic GMP-Dependent Protein Kinase Type I
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