Signaling and Circuitry of Multiple MAPK Pathways Revealed by a Matrix of Global Gene Expression Profiles
Copyright policy )Signaling and Circuitry of Multiple MAPK Pathways Revealed by a Matrix of Global Gene Expression Profiles
Genome-wide transcript profiling was used to monitor signal transduction during yeast pheromone response. Genetic manipulations allowed analysis of changes in gene expression underlying pheromone signaling, cell cycle control, and polarized morphogenesis. A two-dimensional hierarchical clustered matrix, covering 383 of the most highly regulated genes, was constructed from 46 diverse experimental conditions. Diagnostic subsets of coexpressed genes reflected signaling activity, cross talk, and overlap of multiple mitogen-activated protein kinase (MAPK) pathways. Analysis of the profiles specified by two different MAPKs—Fus3p and Kss1p—revealed functional overlap of the filamentous growth and mating responses. Global transcript analysis reflects biological responses associated with the activation and perturbation of signal transduction pathways.
- Queen's University Canada
- Mount Sinai Health System United States
- Lunenfeld-Tanenbaum Research Institute Canada
- Mount Sinai Hospital Canada
- Mount Sinai Hospital United States
Saccharomyces cerevisiae Proteins, MAP Kinase Signaling System, Gene Expression Profiling, Lipoproteins, G1 Phase, Cell Cycle Proteins, Saccharomyces cerevisiae, Pheromones, Fungal Proteins, Repressor Proteins, Gene Expression Regulation, Fungal, Multigene Family, Genome, Fungal, Mitogen-Activated Protein Kinases, Mating Factor, Peptides, Protein Kinase C, Cyclin-Dependent Kinase Inhibitor Proteins, Oligonucleotide Array Sequence Analysis, Transcription Factors
Saccharomyces cerevisiae Proteins, MAP Kinase Signaling System, Gene Expression Profiling, Lipoproteins, G1 Phase, Cell Cycle Proteins, Saccharomyces cerevisiae, Pheromones, Fungal Proteins, Repressor Proteins, Gene Expression Regulation, Fungal, Multigene Family, Genome, Fungal, Mitogen-Activated Protein Kinases, Mating Factor, Peptides, Protein Kinase C, Cyclin-Dependent Kinase Inhibitor Proteins, Oligonucleotide Array Sequence Analysis, Transcription Factors
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