Tissue‐specific alternative splicing of mouse brain type ryanodine receptor/calcium release channel mRNA
Copyright policy )Tissue‐specific alternative splicing of mouse brain type ryanodine receptor/calcium release channel mRNA
We detected alternative splicing of the mouse brain type ryanodine receptor (RyR3) mRNA. The splicing variant was located in the transmembrane segment. The non‐splicing type (RyR3‐II) included a stretch of 341 bp, and that of the 13th codon was stop codon TAA. Reverse transcription‐polymerase chain reaction (RT‐PCR) analysis shows that RyR3‐II mRNA was expressed in various peripheral tissues and brain at all developmental stages. However, interestingly, the splicing type (RyR3‐I) mRNA was detected only in the cerebrum. These findings suggest that the splicing variants RyR3‐I and RyR3‐II may generate functional differences of RyR3 in a tissue‐specific manner.
- Kagawa University Japan
Aging, Molecular Sequence Data, RT-PCR, Muscle Proteins, Polymerase Chain Reaction, Embryonic and Fetal Development, Mice, Animals, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular, Codon, Mice, Inbred BALB C, Mouse brain, Base Sequence, Brain, Gene Expression Regulation, Developmental, Ryanodine Receptor Calcium Release Channel, Alternative Splicing, Ryanodine receptor, Animals, Newborn, Organ Specificity, Calcium Channels, Calcium release channel, Alternative splicing
Aging, Molecular Sequence Data, RT-PCR, Muscle Proteins, Polymerase Chain Reaction, Embryonic and Fetal Development, Mice, Animals, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular, Codon, Mice, Inbred BALB C, Mouse brain, Base Sequence, Brain, Gene Expression Regulation, Developmental, Ryanodine Receptor Calcium Release Channel, Alternative Splicing, Ryanodine receptor, Animals, Newborn, Organ Specificity, Calcium Channels, Calcium release channel, Alternative splicing
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