Organization of the Human and Mouse Low-affinity FcγR Genes: Duplication and Recombination
Copyright policy )Organization of the Human and Mouse Low-affinity FcγR Genes: Duplication and Recombination
Receptors for immunoglobulin G immune complexes (FcγRII and FcγRIII) are expressed on most hematopoietic cells and show much structural and functional diversity. In order to determine the genetic basis for this diversity, a family of genes encoding the human and mouse receptors was isolated and characterized. Humans have five distinct genes for low-affinity FcγRs, in contrast to two in the mouse. With the use of yeast artificial chromosomes, the genes encoding the human receptors were oriented and linked, which established the structure of this complex locus. Comparison of the human and mouse genes generated a model for the evolutionary amplification of this locus.
- University of Mary United States
- Kettering University United States
- Washington University in St. Louis United States
Recombination, Genetic, Base Sequence, Genome, Human, Molecular Sequence Data, Receptors, IgG, Restriction Mapping, Exons, Receptors, Fc, Antigens, Differentiation, Introns, Blotting, Southern, Mice, Immunoglobulin G, Multigene Family, Mutation, Animals, Humans, Spleen
Recombination, Genetic, Base Sequence, Genome, Human, Molecular Sequence Data, Receptors, IgG, Restriction Mapping, Exons, Receptors, Fc, Antigens, Differentiation, Introns, Blotting, Southern, Mice, Immunoglobulin G, Multigene Family, Mutation, Animals, Humans, Spleen
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