Views provided by UsageCountsDefault mode network connectivity is linked to cognitive functioning and CSF Aβ1–42 levels in Alzheimer’s disease
Copyright policy ) Celebi O.; Uzdogan A.; Oguz K.K.; Has A.C.; Dolgun A.; Cakmakli G.Y.; Akbiyik F.; Elibol B.; Saka E.;
Default mode network connectivity is linked to cognitive functioning and CSF Aβ1–42 levels in Alzheimer’s disease
Changes in the default mode network (DMN) activity are early features of Alzheimer's disease (AD) and may be linked to AD-specific Aβ pathology.Cognitive profiles; DMN connectivity alterations; and cerebrospinal fluid (CSF) amyloid beta (Aβ)1-42, total tau, phosphorylated tau 181, and α-synuclein levels were studied in 21 patients with AD and 10 controls.DMN activity is altered in AD. Posterior cingulate cortex (PCC) functional connectivity with other parts of DMN was related to cognitive function scores. The reduction of connectivity of the dorsal PCC with the retrosplenial cortex on the right side was closely related to decreased CSF Aβ1-42 levels in patients with AD.The dorsal PCC and retrosplenial cortex may have special importance in the pathogenesis and cognitive findings of AD.
- Hacettepe University Turkey
- Bilkent University Turkey
Male, Posterior cingulate cortex, brain, Resting functional magnetic resonance imaging, tau Proteins, Gyrus Cinguli, tau protein, cerebrospinal fluid, brain cortex, Cognition, male, Alzheimer Disease, middle aged, alpha synuclein, Humans, human, nuclear magnetic resonance imaging, Phosphorylation, pathophysiology, Aged, Cerebral Cortex, Amyloid beta-Peptides, phosphorylation, cingulate gyrus, Brain, Retrosplenial cortex, Biomarker, Alzheimer's disease, Middle Aged, amyloid beta-protein (1-42), biological marker, Magnetic Resonance Imaging, Peptide Fragments, aged, female, peptide fragment, amyloid beta protein, physiology, alpha-Synuclein, nerve cell network, pathology, Female, Alzheimer disease, Nerve Net, Cognition Disorders, Biomarkers
Male, Posterior cingulate cortex, brain, Resting functional magnetic resonance imaging, tau Proteins, Gyrus Cinguli, tau protein, cerebrospinal fluid, brain cortex, Cognition, male, Alzheimer Disease, middle aged, alpha synuclein, Humans, human, nuclear magnetic resonance imaging, Phosphorylation, pathophysiology, Aged, Cerebral Cortex, Amyloid beta-Peptides, phosphorylation, cingulate gyrus, Brain, Retrosplenial cortex, Biomarker, Alzheimer's disease, Middle Aged, amyloid beta-protein (1-42), biological marker, Magnetic Resonance Imaging, Peptide Fragments, aged, female, peptide fragment, amyloid beta protein, physiology, alpha-Synuclein, nerve cell network, pathology, Female, Alzheimer disease, Nerve Net, Cognition Disorders, Biomarkers
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This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Influence provided by BIP!impulseImpulse provided by BIP!
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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