Evaluate the effects of the single nucleotide polymorphism (SNP) rs3834458 in the fatty acid desaturase 2 gene (FADS2) on n-3 long-chain polyunsaturated fatty acid (LC-PUFA) levels using statistical meta-analysis.Literatures pertaining to the relationship between the SNP rs3834458 and LC-PUFA were retrieved from three electronic databases. Original information was analyzed using RevMan 5.3, including single statistics, test for heterogeneity, summary statistics and evaluation of publication bias.In total, five pieces of literature were retrieved and divided into seven trials. We observed that the minor allele (Tdel+deldel) carriers of rs3834458 had higher linolenic acid levels (P < 0.00001) and lower eicosapentaenoic acid (P < 0.00001), docosapentenoic acid (P = 0.005) and docosahexaenoic acid (P < 0.00001) levels compared to those of carrying major allele homozygote (TT).This meta-analysis indicates that minor allele of rs3834458 in FADS2 may result in lower activity of delta-6 desaturase leading to higher ALA and lower EPA, DPA and DHA in blood.