Endocytosis by Numb breaks Notch symmetry at cytokinesis
Copyright policy )Endocytosis by Numb breaks Notch symmetry at cytokinesis
Cell-fate diversity can be generated by the unequal segregation of the Notch regulator Numb at mitosis in both vertebrates and invertebrates. Whereas the mechanisms underlying unequal inheritance of Numb are understood, how Numb antagonizes Notch has remained unsolved. Live imaging of Notch in sensory organ precursor cells revealed that nuclear Notch is detected at cytokinesis in the daughter cell that does not inherit Numb. Numb and Sanpodo act together to regulate Notch trafficking and establish directional Notch signalling at cytokinesis. We propose that unequal segregation of Numb results in increased endocytosis in one daughter cell, hence asymmetry of Notch at the cytokinetic furrow, directional signalling and binary fate choice.
- Institut Pasteur France
- Centre national de la recherche scientifique France
Cell Nucleus, Dynamins, Receptors, Notch, Green Fluorescent Proteins, Microfilament Proteins, Time-Lapse Imaging, Endocytosis, Animals, Genetically Modified, Juvenile Hormones, Luminescent Proteins, Drosophila melanogaster, Microscopy, Fluorescence, Mutation, Animals, Drosophila Proteins, RNA Interference, Cytokinesis, Protein Binding
Cell Nucleus, Dynamins, Receptors, Notch, Green Fluorescent Proteins, Microfilament Proteins, Time-Lapse Imaging, Endocytosis, Animals, Genetically Modified, Juvenile Hormones, Luminescent Proteins, Drosophila melanogaster, Microscopy, Fluorescence, Mutation, Animals, Drosophila Proteins, RNA Interference, Cytokinesis, Protein Binding
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