THE EFFECT OF LEPTIN ON THE VENTILATORY RESPONSETO HYPEROXIA
Copyright policy )THE EFFECT OF LEPTIN ON THE VENTILATORY RESPONSETO HYPEROXIA
Leptin-deficient mice show a blunted response to hypercapnia explained by central nervous system effects. The impact of leptin on peripheral chemoreceptor function is unclear. Therefore, 9 mutant (ob/ob) and 9 wild-type (+/+) mice were exposed to room air or 100% oxygen and respiratory rate (RR) and tidal volume (Vt) were measured. Subsequently, ob/ob mice received either leptin or vehicle and measurements were repeated. Compared to baseline, for +/+ mice, RR decreased significantly by 9.4% +/- 3.0% (means +/- SD), whereas Vt remained unchanged. Transition from normoxia to hyperoxia did not change RR and Vt in untreated ob/ob mice, whereas after leptin treatment, RR and Vt decreased significantly. Leptin deficiency abolishes the response to hyperoxia, which is restored by leptin replacement. Thus, leptin seems to be influential for a competent peripheral chemoreceptor function.
- Johns Hopkins University United States
Leptin, Male, Body Weight, Mice, Obese, Hyperoxia, Mice, Inbred C57BL, Oxygen, Eating, Mice, Respiratory Mechanics, Animals, Obesity, Injections, Intraperitoneal, Plethysmography, Whole Body
Leptin, Male, Body Weight, Mice, Obese, Hyperoxia, Mice, Inbred C57BL, Oxygen, Eating, Mice, Respiratory Mechanics, Animals, Obesity, Injections, Intraperitoneal, Plethysmography, Whole Body
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