Chromosomal localization of GABAA receptor subunit genes: relationship to human genetic disease
Copyright policy )Chromosomal localization of GABAA receptor subunit genes: relationship to human genetic disease
Hybridization of GABAA receptor probes to human chromosomes in situ and to DNA from sorted human chromosomes has localized the genes encoding a beta subunit and three isoforms of the alpha subunit. The alpha 2 and beta genes are both located on chromosome 4 in bands p12-p13 and may be adjacent. The alpha 1 gene is on chromosome 5 (bands q34-q35) and the alpha 3 gene is on the X chromosome. The alpha 3 locus was mapped also on the mouse X chromosome using genetic break-point analysis in an interspecies pedigree. The combined results locate the human alpha 3 gene within band Xq28, in a location that makes it a candidate gene for the X-linked form of manic depression.
- Heidelberg University Germany
- University of California, San Francisco United States
- University of Oxford United Kingdom
Mice, Genetic Diseases, Inborn, Animals, Chromosome Mapping, Humans, Nucleic Acid Hybridization, DNA, Lymphocytes, Receptors, GABA-A
Mice, Genetic Diseases, Inborn, Animals, Chromosome Mapping, Humans, Nucleic Acid Hybridization, DNA, Lymphocytes, Receptors, GABA-A
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).143 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!