Genome-wide Association Study of Smoking Initiation and Current Smoking
Copyright policy )Genome-wide Association Study of Smoking Initiation and Current Smoking
For the identification of genes associated with smoking initiation and current smoking, genome-wide association analyses were carried out in 3497 subjects. Significant genes that replicated in three independent samples (n = 405, 5810, and 1648) were visualized into a biologically meaningful network showing cellular location and direct interaction of their proteins. Several interesting groups of proteins stood out, including glutamate receptors (e.g., GRIN2B, GRIN2A, GRIK2, GRM8), proteins involved in tyrosine kinase receptor signaling (e.g., NTRK2, GRB14), transporters (e.g., SLC1A2, SLC9A9) and cell-adhesion molecules (e.g., CDH23). We conclude that a network-based genome-wide association approach can identify genes influencing smoking behavior.
- Universitätsmedizin Göttingen Germany
- University of Queensland Australia
- University of Amsterdam Netherlands
- Karolinska Institute Sweden
- University Medical Center Groningen Netherlands
DISORDER, Netherlands Twin Register (NTR), Adult, Male, GENES, EMC NIHES-01-64-01, 610, MOLECULAR-GENETICS, C1, SDG 3 - Good Health and Well-being, Genetics, Humans, Genetics(clinical), Genetics & Heredity, Smoking, LINKAGE ANALYSES, Receptor Protein-Tyrosine Kinases, MAJOR DEPRESSION, Middle Aged, NICOTINE DEPENDENCE, ADDICTION, Receptors, Glutamate, ADULT TWINS, Female, Smoking Cessation, CIGARETTE-SMOKING, Cell Adhesion Molecules, BEHAVIOR, Genome-Wide Association Study, Protein Binding, Signal Transduction
DISORDER, Netherlands Twin Register (NTR), Adult, Male, GENES, EMC NIHES-01-64-01, 610, MOLECULAR-GENETICS, C1, SDG 3 - Good Health and Well-being, Genetics, Humans, Genetics(clinical), Genetics & Heredity, Smoking, LINKAGE ANALYSES, Receptor Protein-Tyrosine Kinases, MAJOR DEPRESSION, Middle Aged, NICOTINE DEPENDENCE, ADDICTION, Receptors, Glutamate, ADULT TWINS, Female, Smoking Cessation, CIGARETTE-SMOKING, Cell Adhesion Molecules, BEHAVIOR, Genome-Wide Association Study, Protein Binding, Signal Transduction
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