Aberrant overexpression of CD14 on granulocytes sensitizes the innate immune response in mDia1 heterozygous del(5q) MDS
Copyright policy )Aberrant overexpression of CD14 on granulocytes sensitizes the innate immune response in mDia1 heterozygous del(5q) MDS
Key PointsmDia1 deficiency led to a cell-autonomous overexpression of CD14 on granulocytes and a hypersensitive innate immune response. mDia1 heterozygous and knockout mice developed age-dependent MDS that was accelerated by chronic stimulation of the innate immunity.
- Northwestern University United States
- Harvard University United States
- Dana-Farber Cancer Institute United States
- Boston Children's Hospital United States
- John Radcliffe Hospital United Kingdom
Lipopolysaccharides, Male, Mice, Knockout, Heterozygote, Lipopolysaccharide Receptors, Formins, Bone Marrow Cells, Immunity, Innate, Mice, Gene Expression Regulation, Myelodysplastic Syndromes, Animals, Chromosomes, Human, Pair 5, Humans, Female, RNA, Messenger, Chromosome Deletion, Carrier Proteins, Adaptor Proteins, Signal Transducing, Granulocytes
Lipopolysaccharides, Male, Mice, Knockout, Heterozygote, Lipopolysaccharide Receptors, Formins, Bone Marrow Cells, Immunity, Innate, Mice, Gene Expression Regulation, Myelodysplastic Syndromes, Animals, Chromosomes, Human, Pair 5, Humans, Female, RNA, Messenger, Chromosome Deletion, Carrier Proteins, Adaptor Proteins, Signal Transducing, Granulocytes
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