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IUBMB Life
Article . 2004 . Peer-reviewed
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IUBMB Life
Article . 2005
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Evidence for Na+/Ca2+ Exchanger 1 Association with Caveolin‐1 and ‐2 in C6 Glioma Cells

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2004 English Publisher:WileyJournal:IUBMB Life, volume 56, pages 621-627 (issn: 1521-6543, eissn: 1521-6551, Copyright policy )
Authors: Yun Tai Kim; Sun Young Shin; Chang Kook Suh; Seok Ho Cha; Sang Yong Jung; Jin-Oh Kwak; Yong Joo Park; +1 Authors

doi: 10.1080/15216540400020353

pmid: 15814461

Evidence for Na+/Ca2+ Exchanger 1 Association with Caveolin‐1 and ‐2 in C6 Glioma Cells

Abstract

AbstractThe purpose of this study is to understand the interaction of Na+‐Ca2+ exchanger (NCX1), that is one of the essential regulators of Ca2+ homeostasis, with caveolin (Cav)‐1 and Cav‐2 in Cav‐3 null cell (rat C6 glioma cell). Both mRNA and protein expression of NCX1, Cav‐1 and Cav‐2 was observed, but no expression of mRNA and protein of Cav‐3 were observed in C6 glioma cells. In isolated caveolae‐enriched membrane fraction, the NCX1, Cav‐1 and Cav‐2 proteins localized in same fractions. The experiment of immuno‐precipitation showed complex formation between the NCX1 and Cavs. Confocal microscopy also supported co‐localization of NCX1 and Cavs at the plasma membrane. Functionally, sodium‐free induced forward mode of NCX1 attenuated by Cav‐1 antisense ODN. When treated cells with Cav‐2 antisense ODN, both reverse and forward mode of NCX1 was attenuated. From these results, in the Cav‐3 lacking cells, the function of NCX1 might be regulated by binding with Cavs. Considering the decrement of NCX1 activity by antisense ODNs, caveolins may play an important role in diverse of pathophysiological process of NCX1‐related disorders in the body. IUBMB Life, 56: 621‐627, 2004

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Keywords

Ions, Binding Sites, Microscopy, Confocal, Reverse Transcriptase Polymerase Chain Reaction, Caveolin 2, Blotting, Western, Caveolin 1, Cell Membrane, Sodium, Oligonucleotides, Antisense, Caveolins, Sodium-Calcium Exchanger, Rats, Cell Line, Tumor, Animals, Humans, Immunoprecipitation, Calcium, RNA, Messenger, Protein Binding

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    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 14
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
14
Average
Average
Top 10%
bronze