
Human PC4 and the yeast ortholog Sub1 have multiple functions in RNA polymerase II transcription. Genome-wide mapping revealed that Sub1 is present on Pol III-transcribed genes. Sub1 was found to interact with components of the Pol III transcription system and to stimulate the initiation and reinitiation steps in a system reconstituted with all recombinant factors. Sub1 was required for optimal Pol III gene transcription in exponentially growing cells.
570, Chromatin Immunoprecipitation, Saccharomyces cerevisiae Proteins, Transcription, Genetic, Chromosome Mapping, Gene Expression Regulation, Developmental, RNA Polymerase III, Saccharomyces cerevisiae, Blotting, Far-Western, DNA-Binding Proteins, Transcription Factors, TFIII, Gene Expression Regulation, Fungal, Mutation, Transcription Factor TFIIIC, Chromosomes, Fungal, Genome, Fungal, DNA, Fungal, Oligonucleotide Array Sequence Analysis, Protein Binding, Transcription Factors
570, Chromatin Immunoprecipitation, Saccharomyces cerevisiae Proteins, Transcription, Genetic, Chromosome Mapping, Gene Expression Regulation, Developmental, RNA Polymerase III, Saccharomyces cerevisiae, Blotting, Far-Western, DNA-Binding Proteins, Transcription Factors, TFIII, Gene Expression Regulation, Fungal, Mutation, Transcription Factor TFIIIC, Chromosomes, Fungal, Genome, Fungal, DNA, Fungal, Oligonucleotide Array Sequence Analysis, Protein Binding, Transcription Factors
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| popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network. | Top 10% | |
| influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Top 10% | |
| impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Top 10% |
