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Proceedings of the National Academy of Sciences
Article . 2009 . Peer-reviewed
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Genome-wide location analysis reveals a role for Sub1 in RNA polymerase III transcription

Authors: TAVENET A; SULEAU A; DUBREUIL G; FERRARI R; DUCROT C; MICHAUT M; AUDE JC; +4 Authors

Genome-wide location analysis reveals a role for Sub1 in RNA polymerase III transcription

Abstract

Human PC4 and the yeast ortholog Sub1 have multiple functions in RNA polymerase II transcription. Genome-wide mapping revealed that Sub1 is present on Pol III-transcribed genes. Sub1 was found to interact with components of the Pol III transcription system and to stimulate the initiation and reinitiation steps in a system reconstituted with all recombinant factors. Sub1 was required for optimal Pol III gene transcription in exponentially growing cells.

Keywords

570, Chromatin Immunoprecipitation, Saccharomyces cerevisiae Proteins, Transcription, Genetic, Chromosome Mapping, Gene Expression Regulation, Developmental, RNA Polymerase III, Saccharomyces cerevisiae, Blotting, Far-Western, DNA-Binding Proteins, Transcription Factors, TFIII, Gene Expression Regulation, Fungal, Mutation, Transcription Factor TFIIIC, Chromosomes, Fungal, Genome, Fungal, DNA, Fungal, Oligonucleotide Array Sequence Analysis, Protein Binding, Transcription Factors

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    selected citations
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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    47
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
Powered by OpenAIRE graph
Found an issue? Give us feedback
selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
47
Top 10%
Top 10%
Top 10%
bronze