descriptionPublicationkeyboard_double_arrow_right Article 03 Jun 1985 English Publisher:WileyJournal:FEBS Letters, volume 185, pages 139-141 (issn: 0014-5793, eissn: 1873-3468,

Authors: Akihiko Hoshi; Takashi Isobe; Takashi Isobe; Tomotaka Shinoda; Fuyuki Kametani; Hiroshi Tonoike;

doi: 10.1016/0014-5793(85)80757-2

pmid: 3922791

Amino acid sequence of an amyloidogenic Bence Jones protein in myeloma‐associated systemic amyloidosis

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Abstract

The complete amino acid sequence of an amyloidogenic Bence Jones protein(NIG‐84) from an individual with myeloma‐associated systemic amyloidosis has been determined. The protein, with a blocked N‐terminus, represents a complete light chain consisting of 217 residues and it has a structural feature characteristic of the Vλ II subgroup. In addition to a two‐residue insertion at positions 28 and 29, it has an additional rare insertion of alanine at position 100. NIG‐84 is an example of the first complete sequence presented for the amyloidogenic Bence Jones protein of the Vλ II subgroup.

Related Organizations

Kobe University
Japan
Tokyo Metropolitan University
Japan

Keywords

Amyloidogenicity, Primary structure, Immunoglobulin Variable Region, Amyloidosis, Subgroup, Immunoglobulin lambda-Chains, Bence Jones protein, Humans, Amino Acid Sequence, Immunoglobulin Constant Regions, Multiple Myeloma, Bence Jones Protein

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