Analysis of killer immunoglobulin-like receptor genes in ankylosing spondylitis
Copyright policy )Analysis of killer immunoglobulin-like receptor genes in ankylosing spondylitis
To assess the possible association of killer immunoglobulin-like receptor (KIR) genes, specifically KIR3DL1, KIR3DS1 and KIR3DL2, with ankylosing spondylitis (AS).14 KIR genes were genotyped in 200 UK patients with AS and 405 healthy controls using multiplex polymerase chain reaction. Sequence-specific oligonucleotide probes were used to subtype 368 cases with AS and 366 controls for 12 KIR3DL2 alleles. Differences in KIR genotypes and KIR3DL2 allele frequencies were assessed using the chi(2) test.KIR3DL1 and KIR3DS1 gene frequencies were very similar in cases with AS and controls (odds ratio = 1.5, 95% confidence interval 0.8 to 3.0, and odds ratio = 1.02, 95% confidence interval 0.2 to 5.3, respectively). KIR3DL2 allele frequencies were not significantly different between cases with AS and controls.Neither the KIR gene content of particular KIR haplotypes nor KIR3DL2 polymorphisms contribute to AS.
- University of Oxford United Kingdom
- Queensland University of Technology Australia
- City Of Hope National Medical Center United States
- University of Queensland Australia
- Nuffield Orthopaedic Centre United Kingdom
haplotype, genetic association, NKB1, genotype, polymerase chain reaction, KIR3DS1, Expression, genetic analysis, Polymerase Chain Reaction, 060407 Genome Structure and Regulation, oligonucleotide probe, Gene Frequency, Receptors, KIR, Receptors, chi square distribution, Odds Ratio, genetics, risk, allele, article, Receptors, KIR3DL1, methodology, spondylitis, Receptors, KIR3DL2, KIR, HLA, priority journal, KIR3DL1 protein, killer cell immunoglobulin like receptor 3DL2, killer cell immunoglobulin like receptor 3DL1, 060406 Genetic Immunology, Receptor, Ankylosing, Risk, Receptors, KIR3DS1, killer cell immunoglobulin like receptor, 572, Genotype, gene frequency, 970111 Expanding Knowledge in the Medical and Health Sciences, diversity, killer cell immunoglobulin like receptor 3DS1, KIR3DL2, C1, KIR3DL1, ankylosing spondylitis, 616, Humans, controlled study, Spondylitis, Ankylosing, human, Alleles, Chi-Square Distribution, Hla-b27, control group, nucleotide sequence, clinical assessment, case control study, cell, major clinical study, United Kingdom, 920116 Skeletal System and Disorders (incl. Arthritis), Haplotypes, Case-Control Studies, 970106 Expanding Knowledge in the Biological Sciences, Cutting Edge, Arthritic Pain, KIR3DL2 protein, multiplex polymerase chain reaction, immunoglobulin, Spondylitis
haplotype, genetic association, NKB1, genotype, polymerase chain reaction, KIR3DS1, Expression, genetic analysis, Polymerase Chain Reaction, 060407 Genome Structure and Regulation, oligonucleotide probe, Gene Frequency, Receptors, KIR, Receptors, chi square distribution, Odds Ratio, genetics, risk, allele, article, Receptors, KIR3DL1, methodology, spondylitis, Receptors, KIR3DL2, KIR, HLA, priority journal, KIR3DL1 protein, killer cell immunoglobulin like receptor 3DL2, killer cell immunoglobulin like receptor 3DL1, 060406 Genetic Immunology, Receptor, Ankylosing, Risk, Receptors, KIR3DS1, killer cell immunoglobulin like receptor, 572, Genotype, gene frequency, 970111 Expanding Knowledge in the Medical and Health Sciences, diversity, killer cell immunoglobulin like receptor 3DS1, KIR3DL2, C1, KIR3DL1, ankylosing spondylitis, 616, Humans, controlled study, Spondylitis, Ankylosing, human, Alleles, Chi-Square Distribution, Hla-b27, control group, nucleotide sequence, clinical assessment, case control study, cell, major clinical study, United Kingdom, 920116 Skeletal System and Disorders (incl. Arthritis), Haplotypes, Case-Control Studies, 970106 Expanding Knowledge in the Biological Sciences, Cutting Edge, Arthritic Pain, KIR3DL2 protein, multiplex polymerase chain reaction, immunoglobulin, Spondylitis
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