ErbB/HER ligands in human breast cancer, and relationships with their receptors, the bio-pathological features and prognosis
Copyright policy )ErbB/HER ligands in human breast cancer, and relationships with their receptors, the bio-pathological features and prognosis
The aim of this study is to provide an expression profile of ErbB/HER ligands in breast cancer. We analysed the relationships with their receptors, the bio-pathological features and prognosis.Epidermal growth factor (EGF), transforming growth factor-alpha (TGFalpha), amphiregulin (AREG), betacellulin (BTC), heparin-binding EGF-like growth factor (HB-EGF), epiregulin (EREG) and neuregulins1-4 (NRG1-4) were quantified in 363 tumours by real-time reverse transcription-polymerase chain reaction using TaqMan probes.Ligands were detected in 80%-96% of the cases, except NRG3 (42%) and EREG (45.5%). At least one ligand was expressed in 304 cases (cut-off: upper quartile). Almost all combinations of receptor and ligand co-expressions were observed, but TGFalpha is preferentially expressed in tumours co-expressing EGFR/HER3, NRG3 in those co-expressing EGFR/HER4, AREG and EREG in those co-expressing HER2/HER4. EGF and AREG were associated with estradiol receptors, small tumour size, low histoprognostic grading, high HER4 levels. TGFalpha, HB-EGF and NRG2 were negatively related to these parameters. In Cox univariate analyses, EGF was a prognostic factor.Our study demonstrates that (i) ErbB/HER ligands, including BTC and EREG, are expressed in most breast cancers; and (ii) TGFalpha, HB-EGF and NRG2 high expressions are related to the biological aggressiveness of the tumours.
- Centre Oscar Lambret France
EGF Family of Proteins, Epidermal Growth Factor, Gene Expression Profiling, Carcinoma, Ductal, Breast, Intracellular Signaling Peptides and Proteins, Breast Neoplasms, Amphiregulin, Disease-Free Survival, Epiregulin, Neoplasm Proteins, ErbB Receptors, Carcinoma, Lobular, Humans, Intercellular Signaling Peptides and Proteins, Female, Neoplasm Invasiveness, Nerve Growth Factors, Betacellulin, Glycoproteins, Heparin-binding EGF-like Growth Factor
EGF Family of Proteins, Epidermal Growth Factor, Gene Expression Profiling, Carcinoma, Ductal, Breast, Intracellular Signaling Peptides and Proteins, Breast Neoplasms, Amphiregulin, Disease-Free Survival, Epiregulin, Neoplasm Proteins, ErbB Receptors, Carcinoma, Lobular, Humans, Intercellular Signaling Peptides and Proteins, Female, Neoplasm Invasiveness, Nerve Growth Factors, Betacellulin, Glycoproteins, Heparin-binding EGF-like Growth Factor
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