Differential human leucocyte allele association between psoriasis and psoriatic arthritis: a family-based association study
Copyright policy )Differential human leucocyte allele association between psoriasis and psoriatic arthritis: a family-based association study
A recent population-based study identified several HLA alleles as conferring a risk for psoriatic arthritis (PsA) among patients with psoriasis. The authors aimed to confirm these results using a family-based association study.PsA probands, psoriasis probands and their first-degree family members were included. All participants were evaluated for the presence of psoriasis and inflammatory arthritis. HLA-B and -C genotyping was performed. The family-based association test was used to test for differences between PsA and psoriasis patients in transmission of candidate alleles from parents to offspring.A total of 178 PsA and 30 psoriasis probands and 561 first degree family members were analysed. The following HLA alleles were over-transmitted to PsA compared with psoriasis: HLA-C*12 (p=0.005), HLA-B*38 (p=0.04), HLA-B*39 (p=0.03), HLA-B*27 (p=0.002).HLA-B*27, HLA-B*38, HLA-B*39 and HLA-C*12 alleles are potential PsA-specific genetic markers among patients with psoriasis.
- University of Toronto Canada
- Mount Sinai Hospital Canada
- University Health Network Canada
- Toronto Western Hospital Canada
- Lunenfeld-Tanenbaum Research Institute Canada
Family Health, Genetic Markers, Male, Genotype, Histocompatibility Testing, Arthritis, Psoriatic, HLA-C Antigens, Linkage Disequilibrium, Gene Frequency, HLA-B Antigens, Population Surveillance, Humans, Female, Genetic Predisposition to Disease, Genetic Association Studies
Family Health, Genetic Markers, Male, Genotype, Histocompatibility Testing, Arthritis, Psoriatic, HLA-C Antigens, Linkage Disequilibrium, Gene Frequency, HLA-B Antigens, Population Surveillance, Humans, Female, Genetic Predisposition to Disease, Genetic Association Studies
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