Bruchpilot Promotes Active Zone Assembly, Ca 2+ Channel Clustering, and Vesicle Release
Copyright policy )Bruchpilot Promotes Active Zone Assembly, Ca 2+ Channel Clustering, and Vesicle Release
The molecular organization of presynaptic active zones during calcium influx–triggered neurotransmitter release is the focus of intense investigation. The Drosophila coiled-coil domain protein Bruchpilot (BRP) was observed in donut-shaped structures centered at active zones of neuromuscular synapses by using subdiffraction resolution STED (stimulated emission depletion) fluorescence microscopy. At brp mutant active zones, electron-dense projections (T-bars) were entirely lost, Ca 2+ channels were reduced in density, evoked vesicle release was depressed, and short-term plasticity was altered. BRP-like proteins seem to establish proximity between Ca 2+ channels and vesicles to allow efficient transmitter release and patterned synaptic plasticity.
- Max Planck Society Germany
- Universität Augsburg Germany
- University of Würzburg Germany
- European Neuroscience Institute Göttingen Germany
- Max Planck Institute for Multidisciplinary Sciences Germany
Male, ddc:610, Models, Neurological, Presynaptic Terminals, Action Potentials, Nerve Tissue Proteins, Larva, Mutation, Synapses, Animals, Drosophila Proteins, Drosophila, Female, Calcium Channels, Synaptic Vesicles
Male, ddc:610, Models, Neurological, Presynaptic Terminals, Action Potentials, Nerve Tissue Proteins, Larva, Mutation, Synapses, Animals, Drosophila Proteins, Drosophila, Female, Calcium Channels, Synaptic Vesicles
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).704 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 0.1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 0.1%
Citations provided by BIP!Popularity provided by BIP!