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Publication . Article . 2007

PGE2/TXB2imbalance in neonatal hypoxemic respiratory failure

Beena G. Sood; Virginia Delaney-Black; Maria Glibetic; Jacob V. Aranda; Xinguang Chen; Seetha Shankaran;
Closed Access
Published: 01 May 2007 Journal: Acta Paediatrica, volume 96, pages 669-673 (issn: 0803-5253, eissn: 1651-2227, Copyright policy )
Publisher: Wiley
Abstract

Background: An imbalance of vaso-constrictor and -dilator mediators has been implicated in the pathogenesis of the pulmonary hypertension accompanying neonatal hypoxemic respiratory failure (NHRF). Aim: To characterize plasma PGE2, TXB2 and their ratio in normal newborns and in those with NHRF. Methods: Twenty newborns with NHRF received inhaled PGE1 (IPGE1) by jet nebulizer in doses of 25, 50, 150 and 300 ng/kg/min followed by weaning. Blood for PGE2 and TXB2 assay using EIA was available in 8 neonates with NHRF prior to IPGE1. Umbilical cord arterial samples were also obtained at delivery from 10 normal newborns to serve as controls. Results: Compared to normal newborns, those with NHRF had significantly lower PGE2/TXB2 ratios after controlling for preterm gestation ( 1.0 in all subjects in the Control group (range 1.1–5.2). Conclusions: Lower PGE2/TXB2 ratio in subjects with NHRF compared with controls reflects a predominance of vaso-constrictor activity in these patients as the basis of pulmonary hypertension. Plasma PGE2/TXB2 ratio may have important implications for the diagnosis and treatment of NHRF.

Subjects by Vocabulary

Microsoft Academic Graph classification: Respiratory disease medicine.disease medicine Umbilical cord medicine.anatomical_structure Weaning Prostaglandin E1 chemistry.chemical_compound chemistry Anesthesia Gestation Pathogenesis business.industry business Pulmonary hypertension Dilator

Medical Subject Headings: lipids (amino acids, peptides, and proteins) circulatory and respiratory physiology respiratory system

Subjects

General Medicine, Pediatrics, Perinatology and Child Health

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