publication . Article . 2008

Brain metabolism in adult chronic hydrocephalus

Daniel Kondziella; Ursula Sonnewald; Mats Tullberg; Carsten Wikkelsö;
Open Access
  • Published: 14 Apr 2008 Journal: Journal of Neurochemistry, volume 106, pages 1,515-1,524 (issn: 0022-3042, eissn: 1471-4159, Copyright policy)
  • Publisher: Wiley
Abstract
Normal pressure hydrocephalus (NPH) is the most frequent form of chronic hydrocephalus in adults. NPH remains underdiagnosed although between 5% and 10% of all demented patients may suffer from this disorder. As dementia is an increasing demographic problem, treatable forms such as in NPH have become a central issue in neurology. Despite the traditional perception of hydrocephalus being a disorder of disturbed CSF dynamics, in NPH metabolic impairment seems at least as important. So far, the only valid animal model of NPH is chronic adult kaolin hydrocephalus. In this model, opening of alternative CSF outflow pathways leads to normal or near-normal intracranial ...
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free text keywords: Biochemistry, Cellular and Molecular Neuroscience, Dementia, medicine.disease, medicine, Hydrocephalus, Central nervous system disease, Cognitive decline, Intracranial pressure, Internal medicine, medicine.medical_specialty, Normal pressure hydrocephalus, Neuroscience, Psychology, Cardiology, Cerebrospinal fluid, Ataxia, medicine.symptom
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