publication . Article . 2006

Increased intrathecal TGF-β1, but not IL-12, IFN-γ and IL-10 levels in Alzheimer’s disease patients

Eugenia Rota; Graziella Bellone; Paola Rocca; Bruno Bergamasco; Giorgio Emanuelli; Patrizia Ferrero;
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  • Published: 11 May 2006 Journal: Neurological Sciences, volume 27, pages 33-39 (issn: 1590-1874, eissn: 1590-3478, Copyright policy)
  • Publisher: Springer Science and Business Media LLC
Abstract
An inflammatory response has been hypothesised to be involved in the pathogenesis of primary dementias, above all Alzheimer’s disease (AD). This study was aimed at evaluating interleukin (IL)-12 and a panel of related cytokine levels in paired CSF and sera of demented patients. IL-12 (p70 heterodimer and total IL-12 p40 chain), interferon (IFN)-γ, IL-10 and transforming growth factor (TGF)-β1 levels were measured in 30 patients with probable Alzheimer’s disease (PrAD), 57 patients with other dementing disorders, including probable vascular dementia (PrVD), Parkinson’s disease (PD) and normal pressure hydrocephalus (NPH), and 25 cognitively normal control subject...
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free text keywords: Internal medicine, medicine.medical_specialty, medicine, Normal pressure hydrocephalus, medicine.disease, Interleukin, Cytokine, medicine.medical_treatment, Cerebrospinal fluid, business.industry, business, Endocrinology, Interleukin 10, Pathogenesis, Dementia, Vascular dementia
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